Letters of Support

Professor Anton Y. Peleg

Director, Department of Infectious Diseases,
Professor of Infectious Diseases and Microbiology
The Alfred Hospital and Monash University

5 June 2017

To Whom It May Concern

Re: New Infrared Spectroscopy-based diagnostic system for detecting bloodstream pathogens associated with sepsis

The Department of Infectious Diseases at the Alfred Hospital is very excited by a new diagnostic test for bloodstream infections associated with sepsis. The technique, which utilizes infrared spectroscopy and computational modelling, has been developed by A/Prof Bayden Wood, Dr. Philip Heraud, David Perez-Guaita and Kamila Kochan at the Monash University Centre for Biospectroscopy. It has the potential to detect bloodstream pathogens at point-of-care and could revolutionise the diagnosis of sepsis.

We are in the process of seeking ethical approval from the Alfred Hospital for a clinical study testing the new diagnostic at point-of-care on febrile patients. The research is part of a multi-site trial with Monash Health and will entail analysing blood samples from patients unwell with suspected sepsis and correlating these results with standard of care blood culture.

The plan is to start the study in the second half of 2017. These activities will be supported by my clinical post doc Dr Christina Chang and involve a Bachelor of Medical Science student Patrick Mclean. Further, the Alfred has purchased a portable ATR FTIR spectrometer and I have applied for $120K AUD from the Alfred Foundation to provide support staff and consumables for the research.

If this pilot clinical trial is successful, it will lead to significant new funding opportunities and larger multi-centre clinical trials with a greater scope of patient outcome and antibiotic use measures as endpoints.

These trials are being designed to expedite TGA approval with the Biotech Resources (Aust) P/L commercial partner.

Yours sincerely,

Professor Anton Y. Peleg


Dr. Tony Korman

Director, Monash Infectious Diseases
Director, Microbiology Monash Health
Adjunct Associate Professor, Department of Medicine, Monash University

2 June 2017

To whom it may concern

Re: New Infrared Spectroscopy-based diagnostic system for detecting bloodstream pathogens associated with sepsis.

Over the past 12 months our team at Monash Infectious Diseases, Monash Health in collaboration with Associate Professor Bayden Wood and Drs Philip Heraud, David Perez-Guaita and Kamila Kochan at Monash University Centre for Biospectroscopy (CfB) have been testing a new technique developed by the team at the CfB that could potentially revolutionize sepsis diagnosis. 

The new technique, which utilizes Attenuated Total Reflection spectroscopy and multivariate modelling, shows extremely promising results and will now be applied to diagnose the pathogens that cause sepsis at point-of-care from patients with suspected sepsis. A multcentre trial, which will commence in the second half of 2017, will involve multiple hospital departments including Emergency and the Intensive Care Units at Monash Health and the Alfred Hospital. If the results from this clinical study are encouraging, we would envisage the program transitioning to a full clinical trial. 

Current standard blood culture methods require several hours to days of incubation to provide preliminary results. The new diagnostic system which allows the detection of sepsis at point-of-care in less than 10 minutes including blood collection represents a major advantage which could transform the early management of lifethreatening sepsis. 

Yours sincerely, 

Dr. Tony Korman